GluN1 hypomorph mice exhibit wide‐ranging behavioral alterations
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GluN1 hypomorph mice exhibit wide-ranging behavioral alterations
The psychotomimetic effects of N-methyl-d-aspartate receptor (NMDA) antagonists such as ketamine and phencyclidine suggest a role for reduced NMDA receptor-mediated neurotransmission in schizophrenia. GluN1 'hypomorph' (GluN1(hypo) ) mice exhibit reduced NMDA receptor expression and have been suggested as a mouse model of schizophrenia. However, NMDA receptors are ubiquitous and are implicated ...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2012
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2012.00767.x